CHARACTERISTICS OF CAUSES, CLINICAL, AND SUBCLINICAL SYMPTOMS IN ADULT PATIENTS WITH IRON DEFICIENCY ANEMIA AT DONG THAP GENERAL HOSPITAL

Trần Thanh Tòng 1 , , Phạm Quốc Duy 2 , Dương Phước Bình 2 , Võ Tấn Phát
1 Dong Thap Hospital image/svg+xml
2 Dong Thap General Hospital
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DOI
10.63947/bvtn.v2i6.16
Published
2026-02-27
Issue Vol. 2 No. 6 (2026): Thách thức trong lão khoa 2026: Những giải pháp điều trị và chăm sóc toàn diện
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Original Research
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Research

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Thanh Tòng T, Quốc Duy P, Phước Bình D, Tấn Phát V. CHARACTERISTICS OF CAUSES, CLINICAL, AND SUBCLINICAL SYMPTOMS IN ADULT PATIENTS WITH IRON DEFICIENCY ANEMIA AT DONG THAP GENERAL HOSPITAL. JHA [Internet]. Vietnam; 2026 Feb. 27 [cited 2026 Mar. 15];2(6):108–113. https://tcsuckhoelaohoa.vn/bvtn/article/view/127 doi: 10.63947/bvtn.v2i6.16
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Abstract

Iron deficiency anemia (IDA) constitutes a significant global health issue. Recent studies indicate that 8-15% of iron deficiency anemia cases are attributable to gastrointestinal malignancies.  This study presents a series of cases to elucidate the clinical and paraclinical characteristics, etiologies of iron deficiency anemia (IDA), and to assess the correlation among certain variables in patients.  The study results included 119 patients aged 16 years and older diagnosed with iron deficiency anemia (IDA) from June 2024 to May 2025 indicated a median age of 60 ± 17.4 years, with 59.7% being female.  Prevalent symptoms of anemia include dizziness, vertigo (96.6%), and pallor of the skin and mucous membranes (82.4%).  The majority of individuals with severe anemia (87.4%) exhibited inadequate bone marrow response (RPI = 0.3 ± 0.1).  The median ferritin level was 10.3 ± 7.5 ng/mL, exhibiting a strong correlation with red blood cell shape (MCV, MCH, MCHC) and transferrin levels.  The primary cause was chronic iron deficiency, with 9.2% attributed to gastrointestinal neoplasms, predominantly affecting men at a rate of 72.7%.  Studies indicate that TMTS is a prevalent condition, particularly among women and the elderly.  It is crucial to screen for the etiology of iron deficiency, particularly gastrointestinal neoplasms, in elderly males.

Keywords

Iron deficiency anemia gastrointestinal neoplasms bone marrow response

References

  1. Manish A. Iron deficiency anemia: A global public health concern. International Journal of Clinical Biochemistry and Research. 2025;11(4):229-36. doi: 10.18231/j.ijcbr.2024.034. DOI: https://doi.org/10.18231/j.ijcbr.2024.034
  2. Camaschella C. Iron deficiency: new insights into diagnosis and treatment. Hematology 2014, the American Society of Hematology Education Program Book. 2015;2015(1):8-13. doi: 10.1182/asheducation-2015.1.8. DOI: https://doi.org/10.1182/asheducation-2015.1.8
  3. Yang J, Li Q, Feng Y, Zeng Y. Iron deficiency and iron deficiency anemia: potential risk factors in bone loss. International Journal of Molecular Sciences. 2023;24(8):6891. doi: 10.3390/ijms24086891. DOI: https://doi.org/10.3390/ijms24086891
  4. Trần Thị Phúc, Đậu Thị Tuyết, Lê Thị Như Hoa, Lê Thị Linh, Ngô Xuân Khoa. Nghiên cứu đặc điểm nguyên nhân, triệu chứng lâm sàng, cận lâm sàng ở bệnh nhân thiếu máu thiếu sắt. Tạp chí Y học Việt Nam. 2022;518(Số chuyên đề):tr.424-30. DOI: https://doi.org/10.51298/vmj.v518i2.3453
  5. Pasricha S-R, Tye-Din J, Muckenthaler MU, Swinkels DW. Iron deficiency. The Lancet. 2021;397(10270):233-48. doi: 10.1016/S0140-6736(20)32594-0. DOI: https://doi.org/10.1016/S0140-6736(20)32594-0
  6. Camaschella C. Iron deficiency. Blood, The Journal of the American Society of Hematology. 2019;133(1):30-9. doi: 10.1182/blood.2022018610. DOI: https://doi.org/10.1182/blood-2018-05-815944
  7. Hà Văn Quang, Nguyễn Văn Bằng, Nguyễn Phương Hiền, Nguyễn Thị Thịnh. Một số nguyên nhân gây thiếu máu thiếu sắt ở bệnh nhân điều trị tại Bệnh viện Quân Y 103. Tạp chí Y Dược học Quân sự. 2024;49(8):124-34. doi: 10.56535/jmpm.v49i8.917. DOI: https://doi.org/10.56535/jmpm.v49i8.917
  8. Phạm Văn Tuấn, Nguyễn Quang Tùng, Phạm Thị Thanh Nga, Hoàng Thị Thu Thủy, Hoàng Thị Hồng Diệp, Đỗ Thị Thanh Huyền. Một số đặc điểm xét nghiệm của bệnh nhân thiếu máu thiếu sắt tại Bệnh viện Đại học Y Hà Nội từ tháng 1/2023 đến tháng 4/2023. Tạo chí Y học Việt Nam. 2023;532(Số Đặc Biệt):166-70.
  9. Nguyễn Thị Thu Hà. Nghiên cứu một số biến đổi máu ngoại vi và chuyển hóa sắt trên một số bệnh lý thiếu máu [Luận văn Thạc sỹ y học]: Đại học Y Hà Nội; 2009.
  10. di Martino E, Smith L, Bradley SH, Hemphill S, Wright J, Renzi C, et al. Incidence trends for twelve cancers in younger adults—A rapid review. British journal of cancer. 2022;126(10):1374-86. doi: 10.1038/s41416-022-01704-x. DOI: https://doi.org/10.1038/s41416-022-01704-x
  11. Jericó C, Beverina I, Quintana‐Diaz M, Salvadori U, Melli C, Rondinelli MB, et al. Efficacy and safety of high‐dose intravenous iron as the first‐choice therapy in outpatients with severe iron deficiency anemia. Transfusion. 2020;60(7):1443-9. doi: 10.1111/trf.15870. DOI: https://doi.org/10.1111/trf.15870
  12. Krieg S, Loosen S, Krieg A, Luedde T, Roderburg C, Kostev K. Association between iron deficiency anemia and subsequent stomach and colorectal cancer diagnosis in Germany. Journal of Cancer Research and Clinical Oncology. 2024;150. doi: 10.1007/s00432-023-05534-z. DOI: https://doi.org/10.1007/s00432-023-05534-z
  13. Levi M, Simonetti M, Marconi E, Brignoli O, Cancian M, Masotti A, et al. Gender differences in determinants of iron-deficiency anemia: a population-based study conducted in four European countries. Annals of Hematology. 2019;98:1573-82. doi: 10.1007/s00277-019-03707-w. DOI: https://doi.org/10.1007/s00277-019-03707-w
  14. Vetrano D, Zucchelli A, Marconi E, Levi M, Pegoraro V, Cataldo N, et al. Predictors of iron-deficiency anemia in primary care older adults: a real-world European multi-country longitudinal study. Aging Clinical and Experimental Research. 2020:1-6. doi: 10.1007/s40520-019-01454-6. DOI: https://doi.org/10.1007/s40520-019-01454-6
  15. Means R, Bi C, Wong E, Bare L, McPhaul M. Ferritin reference intervals in a population of working‐age adults without anemia. American Journal of Hematology. 2024;99. doi: 10.1002/ajh.27444. DOI: https://doi.org/10.1002/ajh.27444
  16. Khan A, Khan W, Ayub M, Humayun M, Haroon M. Ferritin Is a Marker of Inflammation rather than Iron Deficiency in Overweight and Obese People. Journal of Obesity. 2016;2016. doi: 10.1155/2016/1937320. DOI: https://doi.org/10.1155/2016/1937320
  17. Martens K, DeLoughery TG. Sex, lies, and iron deficiency: a call to change ferritin reference ranges. Hematology. 2023;2023(1):617-21. doi: 10.1182/hematology.2023000494. DOI: https://doi.org/10.1182/hematology.2023000494

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