Characteristics and Antimicrobial Susceptibility of bacteria causing Pneumonia in Patients with Acute Exacerbation of COPD at Thong Nhat Hospital

Huỳnh Tuấn Cường 1 , , Nguyễn Hoàng Phương Khánh 2 , Nguyễn Hữu Đức 1 , Tô Hồ Xuân Thuận 1
1 Trường ĐH Nguyễn Tất Thành image/svg+xml
2 Dong Nai Technology University image/svg+xml
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DOI
10.63947/bvtn.v2i9.11
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Published
2026-10-01
Issue Vol. 2 No. 9 (2026): A Major Step Forward in Specialized Care: A Milestone Marked by the First Liver Transplant at Thong Nhat Hospital
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Original Research

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Huỳnh TC, Nguyễn HPK, Nguyễn HĐ, Tô HXT. Characteristics and Antimicrobial Susceptibility of bacteria causing Pneumonia in Patients with Acute Exacerbation of COPD at Thong Nhat Hospital. JHA [Internet]. Vietnam; 2026 Oct. 1 [cited 2026 Oct. 16];2(9):83–88. https://tcsuckhoelaohoa.vn/bvtn/article/view/239 doi: 10.63947/bvtn.v2i9.11
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Abstract

Chronic obstructive pulmonary disease (COPD) is common among older adults, while respiratory infection and antimicrobial resistance complicate the management of exacerbations. This study aimed to describe bacterial isolates and antimicrobial resistance in patients with pneumonia during COPD exacerbations at the Department of Respiratory Medicine, Thong Nhat Hospital. A retrospective cross-sectional study included 271 patients admitted to the department from January to December 2025. Variables included age, sex, sputum culture results, bacterial species, and antimicrobial susceptibility. The median age was 73 years (interquartile range, 16), and 243 patients (89.7%) were male. Among 197 patients with sputum cultures, 63 (32.0%) had positive cultures, yielding 75 isolates. Gram-negative bacilli accounted for 66/75 isolates (88.0%); Klebsiella pneumoniae and Pseudomonas aeruginosa each accounted for 17 isolates (22.7%). Acinetobacter baumannii showed 66.7% (6/9) resistance to imipenem and meropenem; Klebsiella aerogenes showed 85.7% (6/7) resistance to piperacillin/tazobactam, cefepime, and ciprofloxacin, and 71.4% (5/7) resistance to meropenem. K. pneumoniae remained 90.9% susceptible to meropenem and 81.8% susceptible to imipenem but only 9.1% susceptible to ciprofloxacin. Gram-negative bacilli predominated among positive cultures. Antibiotic selection should be guided by local microbiological data and adjusted according to susceptibility results, particularly in older patients.

Keywords

COPD acute exacerbation of COPD pneumonia antimicrobial susceptibility antimicrobial resistance older adults

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