ADJUNCTIVE EFFICACY OF ELECTROACUPUNCTURE COMBINED WITH AURICULAR ACUPUNCTURE ON THE GERDQ SCORE IN PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE AT THONG NHAT HOSPITAL
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Abstract
Electroacupuncture combined with auricular acupuncture is considered a potential adjunctive therapy alongside proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD). A controlled clinical intervention study was conducted in GERD patients with a GerdQ score ≥ 8, who were randomly allocated to an intervention group (electroacupuncture combined with auricular acupuncture plus Esomeprazole 40 mg/day) and a control group (Esomeprazole alone), with follow-up assessments at baseline (day 0), day 7, and day 14, to investigate baseline clinical characteristics and treatment efficacy using the GerdQ scale and the 4GerdQ score (the four positive-predictive questions within the GerdQ questionnaire). Sixty-one patients completed the study (30 in the control group, 31 in the intervention group), with comparable baseline characteristics between the two groups (p>0.05). At baseline, the median GerdQ score was 10.0 in both groups (p=0.447); the 4GerdQ score was 8.0 in both groups (p=0.175). After 14 days, the GerdQ score decreased significantly within each group (p<0.001), and the between-group difference at day 14 was also statistically significant (6.0 versus 7.0; p=0.011). Likewise, the 4GerdQ score in the intervention group was significantly lower than in the control group (4.0 versus 5.0; p=0.008), and the reduction from baseline was also significantly greater (p=0.040). Combined electroacupuncture and auricular acupuncture significantly improved both the overall GerdQ score and the 4GerdQ score compared with PPI monotherapy after 14 days of treatment.
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- Wang R, Li Z, Liu S, Zhang D. Global, regional, and national burden of 10 digestive diseases in 204 countries and territories from 1990 to 2019. Front Public Health. 2023;11:1061453. doi: 10.3389/fpubh.2023.1061453. DOI: https://doi.org/10.3389/fpubh.2023.1061453
- Quach DT, Pham QTT, Tran TLT, Vu NTH, Le QD, Nguyen DTN, et al. Clinical characteristics and risk factors of gastroesophageal reflux disease in Vietnamese patients with upper gastrointestinal symptoms undergoing esophagogastroduodenoscopy. JGH open. 2021;5(5):580-4. doi: 10.1002/jgh3.12536. DOI: https://doi.org/10.1002/jgh3.12536
- Savarino V, Dulbecco P, de Bortoli N, Ottonello A, Savarino E. The appropriate use of proton pump inhibitors (PPIs): Need for a reappraisal. Eur J Intern Med. 2017;37:19-24. doi: 10.1016/j.ejim.2016.10.007. DOI: https://doi.org/10.1016/j.ejim.2016.10.007
- 张北华, 周秉舵, 唐旭东. 胃食管反流病中医诊疗专家共识(2023). 中医杂志. 2023;64(18):1935-44. doi: 10.13288/j.11-2166/r.2023.18.019. [Expert consensus on traditional Chinese medicine diagnosis and treatment of gastroesophageal reflux disease (2023)].
- Ghadiani Z, Gorjizadeh N, Azadvari M, Sharifi A, Jamali R. Acupuncture provides a safe strategy to minimize proton pump inhibitor dose in resistant gastroesophageal reflux disease: randomized controlled trial. Dis Esophagus. 2026;39(1):doag001. doi: 10.1093/dote/doag001. DOI: https://doi.org/10.1093/dote/doag001
- Zhu J, Guo Y, Liu S, Su X, Li Y, Yang Y, et al. Acupuncture for the treatment of gastro-oesophageal reflux disease: a systematic review and meta-analysis. Acupunct Med. 2017;35(5):316-23. doi: 10.1136/acupmed-2016-011205. DOI: https://doi.org/10.1136/acupmed-2016-011205
- Han G, Leem J, Lee H, Lee J. Electroacupuncture to treat gastroesophageal reflux disease: study protocol for a randomized controlled trial. Trials. 2016;17(1):246. doi: 10.1186/s13063-016-1371-8. DOI: https://doi.org/10.1186/s13063-016-1371-8
- Huang Y, Liu J, Lv C, Sun C, Meng M, Lowe S, et al. Integrative effects of transcutaneous auricular vagus nerve stimulation on esophageal motility and pharyngeal symptoms via vagal mechanisms in patients with laryngopharyngeal reflux disease. Front Neurosci. 2024;18:1287809. doi: 10.3389/fnins.2024.1287809. DOI: https://doi.org/10.3389/fnins.2024.1287809
- Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med. 2013;35(2):121-6. doi: 10.4103/0253-7176.116232. DOI: https://doi.org/10.4103/0253-7176.116232
- Yuming T, Yuping Z, Yihan L, Ying Z, Jia H, Hanbing S, et al. Acupuncture Improved the Function of the Lower Esophageal Sphincter and Esophageal Motility in Chinese Patients with Refractory Gastroesophageal Reflux Disease Symptoms: A Randomized Trial. Gastroenterol Res Pract. 2023;2023:4645715. doi: 10.1155/2023/4645715. DOI: https://doi.org/10.1155/2023/4645715
- Quach DT, Luu MN, Nguyen PV, Vo UP-P, Vo CH-M. Dietary and lifestyle factors associated with troublesome gastroesophageal reflux symptoms in Vietnamese adults. Front Nutr. 2023;10:1280511. doi: 10.3389/fnut.2023.1280511. DOI: https://doi.org/10.3389/fnut.2023.1280511
- Nguyen TT, Trinh DTT. The traditional medicine patterns in GERD patients at University Medical Center HCMC: a cross-sectional survey. MedPharmRes. 2023;7(4):82-6. doi: 10.32895/UMP.MPR.7.4.10. DOI: https://doi.org/10.32895/UMP.MPR.7.4.10
- Katz PO, Dunbar KB, Schnoll-Sussman FH, Greer KB, Yadlapati R, Spechler SJ. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. Am J Gastroenterol. 2022;117(1):27-56. doi: 10.14309/ajg.0000000000001538. DOI: https://doi.org/10.14309/ajg.0000000000001538
- Hurr TJ. The six-question Gastroesophageal Reflux Disease Questionnaire (GerdQ) cannot accurately quantify reflux and reflux-associated symptoms frequency. Gastroenterol Rep (Oxf). 2022;10:goac043. doi: 10.1093/gastro/goac043. DOI: https://doi.org/10.1093/gastro/goac043
- Yin J, Yin M, Liu T, Qin S. Does Manual Acupuncture Improve Gastroesophageal Reflux Disease Symptoms? A Trial Sequential Meta-Analysis. Complement Med Res. 2025;32(3):233-43. doi: 10.1159/000544956. DOI: https://doi.org/10.1159/000544956
- Liu S, Wang Z, Su Y, Qi L, Yang W, Fu M, et al. A neuroanatomical basis for electroacupuncture to drive the vagal–adrenal axis. Nature. 2021;598(7882):641-5. doi: 10.1038/s41586-021-04001-4. DOI: https://doi.org/10.1038/s41586-021-04001-4
- Zhang X-p, Zhou J, Pan W-b, Huang X, Chen R-h, Liu Z-w, et al. World Federation of Acupuncture-Moxibustion Societies (WFAS) Clinical Practice Guideline on Acupuncture and Moxibustion: Gastroesophageal Reflux Disease (GERD) recommendation summaries. World J Acupunct Moxibustion. 2024;34(3):197-203. doi: 10.1016/j.wjam.2024.03.008. DOI: https://doi.org/10.1016/j.wjam.2024.03.008
- Dickman R, Schiff E, Holland A, Wright C, Sarela SR, Han B, et al. Clinical trial: acupuncture vs. doubling the proton pump inhibitor dose in refractory heartburn. Aliment Pharmacol Ther. 2007;26(10):1333-44. doi: 10.1111/j.1365-2036.2007.03520.x. DOI: https://doi.org/10.1111/j.1365-2036.2007.03520.x
- Nguyen Lam TA, Tran AH, Pham Bui MM, Trinh DTT. Enhancing gastroesophageal reflux disease treatment using thread-embedding and auricular acupuncture: a randomized controlled trial in patients with the Liver Qi Invading Stomach pattern. Eur J Integr Med. 2025;78:102532. doi: 10.1016/j.eujim.2025.102532. DOI: https://doi.org/10.1016/j.eujim.2025.102532
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