SURVEY ON COAGULATION DISORDERS IN PATIENTS WITH SEPSIS ACCORDING TO THE SIC SCORE
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Abstract
To determine the prevalence of coagulopathy in sepsis patients, clinical indicators according to the SOFA score, and laboratory indicators based on the SIC score at Thong Nhat Hospital. To investigate the correlation between the SIC score and disseminated intravascular coagulation (DIC). A cross-sectional descriptive study of sepsis patients aged 18 and older at Thong Nhat Hospital based on the Sepsis-3 criteria from November 2023 to July 2024. Among 106 sepsis patients, 69 (65.1%) were male, with an average age of 69.9 ± 17.1 years. The majority had hypertension (41.5%) and diabetes (26.4%), with infection sources primarily from the respiratory system (44.3%) and gastrointestinal tract (21.7%). The median SOFA score and SOFA (SIC score) were 5 (3 – 7) and 3 (2 – 5), respectively. Multiorgan dysfunction syndrome (MODS) was present in 54.7% of patients. The prevalence of coagulopathy in sepsis patients according to the SIC score was 49.1%. There was a statistically significant difference in the rate of coagulopathy between the multiorgan dysfunction syndrome group, those with thrombocytopenia < 150 G/L; INR > 1.2; aPTT > 37s; D-Dimer > 500ng/ml; total bilirubin > 21µmol/L; Hb < 10.5g/dL (p < 0.05). A positive correlation of r = 0.6 was found between the SIC score and the Overt-DIC score, significant with p < 0.05. Most sepsis patients are elderly with comorbidities. The rate of coagulopathy due to sepsis according to the SIC score is high and correlates with laboratory indicators such as thrombocytopenia, INR, aPTT, D-Dimer, total bilirubin, and Hb. There is a strong positive correlation with the DIC score.
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- Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. Feb 23 2016;315(8):801-10. doi:10.1001/jama.2016.0287
- Nguyễn Phước Nhân, Tôn Thanh Trà, Phạm Thị Ngọc Thảo. Giá trị của thang điểm qSOFA trong tiên lượng tử vong ở bệnh nhân nhiễm khuẩn huyết nhập khoa cấp cứu, bệnh viện Chợ Rẫy. Y Học TP Hồ Chí Minh. 2021;25
- Đoàn Duy Thành, Phan Thị Thanh Hoa, Đồng Phú Khiêm và cộng sự. Một số yếu tố liên quan với rối loạn đông máu ở bệnh nhân SEPSIS tại bệnh viện Bệnh Nhiệt đới Trung ương năm 2019. Truyền nhiễm Việt Nam. 2021;1:4.
- Ishikura H, Nishida T, Murai A, et al. New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study. Crit Care. 2014;18(1):R19. Published 2014 Jan 20. doi:10.1186/cc13700
- Trần Thanh Minh, Lê Bảo Huy, Võ Hoàng Anh và cộng sự. Nghiên Cứu Đặc Điểm Lâm Sàng, Cận Lâm Sàng Của Bệnh Nhân Nhiễm Khuẩn Huyết Tại Bệnh Viện Thống Nhất Tp. Hồ Chí Minh. Tạp chí Y học TPHCM. 2018;23(3):249-255.
- Thiều Thị Trúc Quyên, Huỳnh Văn Ân.Giá trị tiên lượng tử vong của thang điểm SOFA trên bệnh nhân sốc nhiễm khuẩn. Tạp Chí Y Học Việt Nam. 2022;520
- Iba T, Nisio MD, Levy JH, Kitamura N, Thachil J. New criteria for sepsis-induced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open. Sep 27 2017;7(9):e017046. doi:10.1136/bmjopen-2017-017046.
- Schmoch T, Möhnle P, Weigand MA, et al. The prevalence of sepsis-induced coagulopathy in patients with sepsis - a secondary analysis of two German multicenter randomized controlled trials. Ann Intensive Care. Jan 12 2023;13(1):3. doi:10.1186/s13613-022-01093-7
- Iba T, Arakawa M, Di Nisio M, et al. Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality. J Intensive Care Med. Jul 2020;35(7):643-649. doi:10.1177/0885066618773679
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