EVALUATION OF CLINICAL FEATURES, PARACLINICAL FINDINGS, AND TREATMENT OUTCOMES OF GIANT CELL TUMOR OF BONE

Nguyễn Thiên Đức 1 , Võ Thành Toàn 1, 2 ,
1 Vietnam National University Ho Chi Minh City image/svg+xml
2 Thong Nhat Hospital image/svg+xml
* Corresponding author:

Article Information

Metrics
Downloads: 3 Views: 10
DOI
10.63947/bvtn.v1i3.6
Published
2025-07-10
Issue Vol. 1 No. 3 (2025): Adapting to the trend of population aging and an aged population
Section
Original Paper
Categories
Research

Download Article

PDF (Vietnamese)

How to Cite

1.
Thiên Đức N, Thành Toàn V. EVALUATION OF CLINICAL FEATURES, PARACLINICAL FINDINGS, AND TREATMENT OUTCOMES OF GIANT CELL TUMOR OF BONE. JHA [Internet]. Vietnam; 2025 Jul. 10 [cited 2025 Jul. 22];1(3):54–59. https://tcsuckhoelaohoa.vn/bvtn/article/view/61 doi: 10.63947/bvtn.v1i3.6
Loading citation...
Crossref
Scopus
Google Scholar
Europe PMC

Abstract

To evaluate the clinical features, paraclinical findings, and treatment outcomes of giant cell tumor (GCT) of bone. Fifteen patients aged 20 to 40 years with bone lesions underwent surgery and histopathological examination and were diagnosed with “giant cell tumor of bone” between January 2011 and December 2024. There were 6 males and 9 females. The most common tumor location was the tibia (53.3%). The most frequent histological pattern was fibrosis, present in 11 cases (73.3%). The average follow-up duration was 55 months. Local recurrence occurred in 3 out of 15 cases, with no cases of metastasis. The GCT cases in our study shared pathological characteristics with classic GCT populations. No specific histological feature was associated with adverse outcomes. Curettage combined with bone cement filling proved to be an effective treatment option.

Keywords

Giant cell tumor tibia cement curettage

References

  1. Turcotte RE. Giant cell tumor of bone. Orthoped Clin North Am 2006;37(1):35–51. https://doi.org/10.1016/j.ocl.2005.08.005. DOI: https://doi.org/10.1016/j.ocl.2005.08.005
  2. Sobti A, Agrawal P, Agarwala S, Agarwal M. Giant cell tumor of bone-an overview. Arch Bone Jt Surg 2016;4(1):2–9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733230/ Accessed May 19, 2019
  3. Purohit S, Pardiwala DN. Imaging of giant cell tumor of bone. Indian J Orthop 2007;41(2):91–6. doi:10.4103/0019-5413.32037 DOI: https://doi.org/10.4103/0019-5413.32037
  4. Al-Ibraheemi A, Inwards CY, Zreik RT, et al. Histologic spec- trum of giant cell tumor (GCT) of bone in patients 18 years of age and below: a study of 63 patients. Am J Surg Pathol. 2016;40:1702-1712. DOI: https://doi.org/10.1097/PAS.0000000000000715
  5. Broehm CJ, Inwards CY, Al-Ibraheemi A, Wenger DE, Jenkins SM, Jin L, Oliveira AM, Zreik RT, Carter JM, Boland JM, Fritchie KJ. Giant Cell Tumor of Bone in Patients 55 Years and Older: A Study of 34 Patients. Am J Clin Pathol. 2018 Feb 17;149(3):222-233. doi: 10.1093/ajcp/aqx155. PMID: 29425276. DOI: https://doi.org/10.1093/ajcp/aqx155
  6. Campanacci M, Baldini N, Boriani S, et al. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69:106-114. DOI: https://doi.org/10.2106/00004623-198769010-00018
  7. McDonald DJ, Sim FH, McLeod RA, et al. Giant-cell tumor of bone. J Bone Joint Surg Am. 1986;68:235-242. DOI: https://doi.org/10.2106/00004623-198668020-00009
  8. Mnaymneh WA, Dudley HR, Mnaymneh LG. Giant-cell tumor of bone: an analysis and follow-up study of the forty-one cases observed at the Massachusetts General Hospital between 1925 and 1960. J Bone Joint Surg Am. 1964;46:63-75. DOI: https://doi.org/10.2106/00004623-196446010-00006
  9. Czerniak B. Dorfman and Czerniak’s Bone Tumors. 2nd ed. Philadelphia, PA: Elsevier; 2015.
  10. Hodges FJ, Latourette HB, Macintyre RS. Radiologic aspects of giant-cell tumor of bone. Clin Orthop. 1956;7:82-92.

License

© 2025 The Author(s). Published by Journal of Health and Aging.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.