LEFT VENTRICULAR NONCOMPACTION CARDIOMYOPATHY WITH TRIPLE TTN VARIANTS MASQUERADING AS ARRHYTHMIA-INDUCED CARDIOMYOPATHY: A CASE REPORT

Lam Thanh Vi 1 , Ngo Long Van 1 , Tran Nguyen Thao Nhi 1 , Nguyen Thanh Huan 1, 2 ,
1 University of Medicine and Pharmacy at Ho Chi Minh City image/svg+xml
2 Thong Nhat Hospital image/svg+xml
* Corresponding author:

Article Information

Metrics
Downloads: 11 Views: 28
DOI
10.63947/bvtn.v1i5.20
Published
2025-11-01
Issue Vol. 1 No. 5 (2025): Thong Nhat Hospital’s 50-Year Journey - Comprehensive Healthcare and Healthy Aging
Section
Case Report
Categories
Research

Download Article

PDF

How to Cite

1.
Vi LT, Van NL, Nhi TNT, Huan NT. LEFT VENTRICULAR NONCOMPACTION CARDIOMYOPATHY WITH TRIPLE TTN VARIANTS MASQUERADING AS ARRHYTHMIA-INDUCED CARDIOMYOPATHY: A CASE REPORT. JHA [Internet]. Vietnam; 2025 Nov. 1 [cited 2025 Nov. 5];1(5):126–132. https://tcsuckhoelaohoa.vn/bvtn/article/view/78 doi: 10.63947/bvtn.v1i5.20
Loading citation...
Crossref
Scopus
Google Scholar
Europe PMC

Abstract

Left ventricular noncompaction cardiomyopathy (LVNC) can lead to ventricular arrhythmias and may be misdiagnosed as arrhythmia-induced cardiomyopathy (AiCM). While LVNC is associated with genetic abnormalities, AiCM is triggered by arrhythmias and is typically reversible once the arrhythmia is eliminated. We report the case of a 59-year-old woman with LVNC carrying three TTN gene variants: c.100804A>T (p.Met33602Leu, exon 358), c.59200C>G (p.Pro19734Ala, exon 300), and c.52052T>C (p.Val17351Ala, exon 273). The patient was initially diagnosed with AiCM but showed no recovery of left ventricular function after successful catheter ablation of ventricular arrhythmias. Echocardiography and cardiac magnetic resonance imaging confirmed the LVNC phenotype. This case highlights the importance of distinguishing between these two entities in clinical practice.

Keywords

Left ventricular noncompaction cardiomyopathy arrhythmia-induced cardiomyopathy TTN gene

References

  1. Finsterer J, Stöllberger C, Towbin JA. Left ventricular noncompaction cardiomyopathy: cardiac, neuromuscular, and genetic factors. Nature reviews Cardiology. 2017;14(4):224-37. Epub 2017/01/13. doi: 10.1038/nrcardio.2016.207. PubMed PMID: 28079110. DOI: https://doi.org/10.1038/nrcardio.2016.207
  2. Lukas Laws J, Lancaster MC, Ben Shoemaker M, Stevenson WG, Hung RR, Wells Q, et al. Arrhythmias as Presentation of Genetic Cardiomyopathy. 2022;130(11):1698-722. doi: doi:10.1161/CIRCRESAHA.122.319835. DOI: https://doi.org/10.1161/CIRCRESAHA.122.319835
  3. Shoureshi P, Tan AY, Koneru J, Ellenbogen KA, Kaszala K, Huizar JF. Arrhythmia-Induced Cardiomyopathy. 2024;83(22):2214-32. doi: doi:10.1016/j.jacc.2024.03.416.
  4. Shoureshi P, Tan AY, Koneru J, Ellenbogen KA, Kaszala K, Huizar JF. Arrhythmia-Induced Cardiomyopathy: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2024;83(22):2214-32. Epub 2024/05/30. doi: 10.1016/j.jacc.2024.03.416. PubMed PMID: 38811098. DOI: https://doi.org/10.1016/j.jacc.2024.03.416
  5. Bozkurt B, Colvin M, Cook J, Cooper LT, Deswal A, Fonarow GC, et al. Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association. Circulation. 2016;134(23):e579-e646. Epub 2016/11/11. doi: 10.1161/cir.0000000000000455. PubMed PMID: 27832612. DOI: https://doi.org/10.1161/CIR.0000000000000455
  6. Fazio G, Mongiovi M, Sutera L, Novo G, Novo S, Pipitone S. Segmental dyskinesia in Wolff-Parkinson-White syndrome: a possible cause of dilatative cardiomyopathy. International journal of cardiology. 2008;123(2):e31-4. Epub 2007/02/13. doi: 10.1016/j.ijcard.2006.11.109. PubMed PMID: 17292982. DOI: https://doi.org/10.1016/j.ijcard.2006.11.109
  7. Huizar JF, Ellenbogen KA, Tan AY, Kaszala K. Arrhythmia-Induced Cardiomyopathy: JACC State-of-the-Art Review. Journal of the American College of Cardiology. 2019;73(18):2328-44. Epub 2019/05/11. doi: 10.1016/j.jacc.2019.02.045. PubMed PMID: 31072578; PubMed Central PMCID: PMC6538508. DOI: https://doi.org/10.1016/j.jacc.2019.02.045
  8. Watanabe H, Okamura K, Chinushi M, Furushima H, Tanabe Y, Kodama M, et al. Clinical characteristics, treatment, and outcome of tachycardia induced cardiomyopathy. International heart journal. 2008;49(1):39-47. Epub 2008/03/25. doi: 10.1536/ihj.49.39. PubMed PMID: 18360063. DOI: https://doi.org/10.1536/ihj.49.39
  9. Gupta S, Figueredo VM. Tachycardia mediated cardiomyopathy: pathophysiology, mechanisms, clinical features and management. International journal of cardiology. 2014;172(1):40-6. Epub 2014/01/23. doi: 10.1016/j.ijcard.2013.12.180. PubMed PMID: 24447747. DOI: https://doi.org/10.1016/j.ijcard.2013.12.180

License

© 2025 The Author(s). Published by Journal of Health and Aging.

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.