RISK FACTORS ASSOCIATED WITH PROGRESSION TO ACUTE-ON-CHRONIC LIVER FAILURE IN SEVERE ACUTE EXACERBATION OF CHRONIC HEPATITIS B

Nguyen Thi Thu Hai 1 , Bui Huu Hoang 2 , Le Hong Quan 3 , , Nguyen Lam Vinh Phuc 4
1 Tam Anh General Hospital, Ho Chi Minh City, Vietnam
2 Đại học Y Dược Thành phố Hồ Chí Minh image/svg+xml
3 Xuyen A General Hospital, Ho Chi Minh City, Vietnam
4 Nam Sai Gon General Hospital, Ho Chi Minh City, Vietnam
* Tác giả liên hệ:

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Lượt tải: 9 Lượt xem: 13
DOI
10.63947/bvtn.v1i5.14
Xuất bản
01-11-2025
Số Tập 1 Số 5 (2025): Thong Nhat Hospital’s 50-Year Journey - Comprehensive Healthcare and Healthy Aging
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Thi Thu Hai N, Huu Hoang B, Hong Quan L, Lam Vinh Phuc N. RISK FACTORS ASSOCIATED WITH PROGRESSION TO ACUTE-ON-CHRONIC LIVER FAILURE IN SEVERE ACUTE EXACERBATION OF CHRONIC HEPATITIS B. JHA [Internet]. Vietnam; 2025 tháng 11 1 [cited 2025 tháng 11 5];1(5):93–99. https://tcsuckhoelaohoa.vn/bvtn/article/view/136 doi: 10.63947/bvtn.v1i5.14
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Tóm tắt

Hepatitis B virus (HBV) infection is a prevalent and serious infectious disease. Severe acute exacerbation of chronic hepatitis B occurs in 40-50% of patients with chronic hepatitis B, which can progress to acute-on-chronic liver failure (ACLF) when their liver damage worsens. Early diagnosis and treatment play an important role in the survival of patients with ACLF. To investigate risk factors associated with the progression of ACLF in severe acute exacerbation of chronic hepatitis B. A retrospective, cross-sectional study with longitudinal follow-up was conducted on 69 patients with severe acute exacerbation of chronic hepatitis B, conducted at the Department of Gastroenterology, The University of Medicine Center of Ho Chi Minh City from January 2022 to December 2023. Of the 69 patients, 30 (43.5%) progressed to ACLF. Univariate analysis identified a history of compensated cirrhosis (OR = 9.04; 95% CI: 3.0–27.2), spider angiomas (OR = 4.43; 95% CI: 1.54–12.75), palmar erythema (OR = 5.07; 95% CI: 1.75–14.64), lower serum sodium (OR = 1.18; 95% CI: 1.02–1.37), higher total bilirubin (OR = 1.06; 95% CI: 1.01–1.12), and lower serum albumin (OR = 1.29; 95% CI: 1.13–1.47) as significant risk factors for ACLF progression in severe acute exacerbation of chronic HBV. Risk factors associated with the progression of ACLF in severe acute exacerbation of chronic hepatitis B are a history of compensated cirrhosis, spider angiomas, palmar erythema, serum sodium, total bilirubin, and serum albumin. Serum albumin is an independent risk factor.

 

Từ khóa

acute-on-chronic liver failure severe acute exacerbation of chronic hepatitis B chronic hepatitis B

Tài liệu tham khảo

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