EVALUATION OF MELANIN INHIBITION EFFICIENCY OF C-PHYCOCYANIN EXTRACTED FROM SPIRULINAON ZEBRAFISH (DANIO RERIO) MODEL

To Minh-Quan 1 , Lai Dinh-Bien 2 , Tran Thi Mai-Chinh 2 , Le Tran Tram-Anh 2 , Quan Quoc-Dang 1, 3 ,
1 Trường Đại học Khoa học Tự nhiên, Đại học Quốc gia Thành phố Hồ Chí Minh image/svg+xml
2 Trường Đại học Công Thương TP. Hồ Chí Minh image/svg+xml
3 Bệnh viện Thống Nhất image/svg+xml
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Lượt tải: 16 Lượt xem: 41
DOI
10.63947/bvtn.v1i5.19
Xuất bản
01-11-2025
Số Tập 1 Số 5 (2025): Thong Nhat Hospital’s 50-Year Journey - Comprehensive Healthcare and Healthy Aging
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1.
Minh-Quan T, Dinh-Bien L, Thi Mai-Chinh T, Tram-Anh LT, Quoc-Dang Q. EVALUATION OF MELANIN INHIBITION EFFICIENCY OF C-PHYCOCYANIN EXTRACTED FROM SPIRULINAON ZEBRAFISH (DANIO RERIO) MODEL. JHA [Internet]. Vietnam; 2025 tháng 11 1 [cited 2025 tháng 11 5];1(5):122–125. https://tcsuckhoelaohoa.vn/bvtn/article/view/137 doi: 10.63947/bvtn.v1i5.19
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Tóm tắt

Melanin overproduction can lead to hyperpigmentation issues such as freckles and melasma, impacting aesthetics and health. This study investigates the inhibitory effects of C-Phycocyanin (C-PC) extracted from Spirulina on melanin synthesis using a zebrafish (Danio rerio) model. C-PC demonstrated significant tyrosinase inhibition and reduced melanin content in zebrafish embryos in a dosedependent manner. The IC50 value of C PC for tyrosinase inhibition was determined to be 38.36 ± 19 µg/mL. At the highest tested concentration (10 µg/mL), C-PC reduced melanin content in zebrafish embryos by approximately 48.57%, compared to 71.08% inhibition observed with kojic acid. Importantly, C-PC exhibited low toxicity, with treated embryos maintaining normal morphology and viability. The findings suggest the potential application of C-PC as a natural depigmenting agent in cosmetic formulations.

 

Từ khóa

C-Phycocyanin Spirulina Melanin Inhibition Tyrosinase Zebrafish Model

Tài liệu tham khảo

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