THE CONTROL OF SOME HORMONES RELATING TO CUTANEOUS AGING: MECHANISMS, MANIFESTATIONS, AND MANAGEMENT

Huynh Thi Xuan Tam 1 ,
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DOI
10.63947/bvtn.v2i7.1
Xuất bản
27-02-2026
Số Tập 2 Số 7 (2026): Multimodal approaches in geriatrics
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Thi Xuan Tam H. THE CONTROL OF SOME HORMONES RELATING TO CUTANEOUS AGING: MECHANISMS, MANIFESTATIONS, AND MANAGEMENT. JHA [Internet]. Vietnam; 2026 tháng 2 27 [cited 2026 tháng 2 28];2(7):1–12. https://tcsuckhoelaohoa.vn/bvtn/article/view/174 doi: 10.63947/bvtn.v2i7.1
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Tóm tắt

To summarize current evidence on the interaction between endocrine factors and skin aging, with a focus on the role of hormones and endocrine pathways. This review was conducted through a literature search in PubMed using the keywords “hormone,” “skin aging,” and “cutaneous aging.” Studies addressing the role of hormones in age-related changes of skin physiology were reviewed and synthesized. Skin aging is closely associated with hormonal changes. In women, the sharp decline in estrogen during menopause is a central factor driving aging, leading to reduced collagen and elastin synthesis, dermal thinning, loss of hydration, and increased sensitivity to environmental stressors. In men, the gradual decrease in testosterone also contributes to skin aging, though typically less prominently. Overall, the evidence highlights hormones as key regulators of skin health and resilience. The changes of some hormones play an important role in the process of skin aging. These findings underscore the potential of future skin rejuvenation strategies targeting endocrine pathways.

Từ khóa

estrogen progesterone testosterone

Tài liệu tham khảo

  1. Hussein RS, Bin Dayel S, Abahussein O, El-Sherbiny AA. Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. J Cosmet Dermatol. 2025;24(2):e16688. Epub 20241127. doi: 10.1111/jocd.16688. PubMed PMID: 39604792; PubMed Central PMCID: PMC11845971.
  2. Thornton MJ. Estrogens and aging skin. Dermatoendocrinol. 2013;5(2):264-70. doi: 10.4161/derm.23872. PubMed PMID: 24194966; PubMed Central PMCID: PMC3772914.
  3. Zhang S, Duan E. Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplant. 2018;27(5):729-38. Epub 20180425. doi: 10.1177/0963689717725755. PubMed PMID: 29692196; PubMed Central PMCID: PMC6047276.
  4. Durai PC, Thappa DM, Kumari R, Malathi M. Aging in elderly: chronological versus photoaging. Indian J Dermatol. 2012;57(5):343-52. doi: 10.4103/0019-5154.100473. PubMed PMID: 23112352; PubMed Central PMCID: PMC3482795.
  5. Naharro-Rodriguez J, Bacci S, Hernandez-Bule ML, Perez-Gonzalez A, Fernandez-Guarino M. Decoding Skin Aging: A Review of Mechanisms, Markers, and Modern Therapies. Cosmetics. 2025;12(4):144. doi: ARTN 144
  6. 10.3390/cosmetics12040144. PubMed PMID: WOS:001557338300001.
  7. Shin SH, Lee YH, Rho NK, Park KY. Skin aging from mechanisms to interventions: focusing on dermal aging. Front Physiol. 2023;14:1195272. Epub 20230510. doi: 10.3389/fphys.2023.1195272. PubMed PMID: 37234413; PubMed Central PMCID: PMC10206231.
  8. Rittié L, Fisher GJ. Natural and sun-induced aging of human skin. Cold spring harbor perspectives in medicine. 2015;5(1):a015370.
  9. Lephart ED, Naftolin F. Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin. Dermatol Ther (Heidelb). 2021;11(1):53-69. Epub 20201126. doi: 10.1007/s13555-020-00468-7. PubMed PMID: 33242128; PubMed Central PMCID: PMC7859014.
  10. Raine-Fenning NJ, Brincat MP, Muscat-Baron Y. Skin aging and menopause : implications for treatment. Am J Clin Dermatol. 2003;4(6):371-8. doi: 10.2165/00128071-200304060-00001. PubMed PMID: 12762829.
  11. Stevenson S, Thornton J. Effect of estrogens on skin aging and the potential role of SERMs. Clin Interv Aging. 2007;2(3):283-97. doi: 10.2147/cia.s798. PubMed PMID: 18044179; PubMed Central PMCID: PMC2685269.
  12. Campbell L, Emmerson E, Davies F, Gilliver SC, Krust A, Chambon P, et al. Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med. 2010;207(9):1825-33. Epub 20100823. doi: 10.1084/jem.20100500. PubMed PMID: 20733032; PubMed Central PMCID: PMC2931162.
  13. Chaudhary SC, Singh T, Talwelkar SS, Srivastava RK, Arumugam A, Weng Z, et al. Erb-041, an estrogen receptor-beta agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer Prev Res (Phila). 2014;7(2):186-98. Epub 20131111. doi: 10.1158/1940-6207.CAPR-13-0276. PubMed PMID: 24217507; PubMed Central PMCID: PMC3946228.
  14. Zouboulis CC, Blume-Peytavi U, Kosmadaki M, Roo E, Vexiau-Robert D, Kerob D, et al. Skin, hair and beyond: the impact of menopause. Climacteric. 2022;25(5):434-42. Epub 20220404. doi: 10.1080/13697137.2022.2050206. PubMed PMID: 35377827.
  15. Viscomi B, Muniz M, Sattler S. Managing Menopausal Skin Changes: A Narrative Review of Skin Quality Changes, Their Aesthetic Impact, and the Actual Role of Hormone Replacement Therapy in Improvement. J Cosmet Dermatol. 2025;24 Suppl 4(Suppl 4):e70393. doi: 10.1111/jocd.70393. PubMed PMID: 40847905; PubMed Central PMCID: PMC12374573.
  16. Bravo B, Penedo L, Carvalho R, Dal Vesco C, Calomeni M, Gapanowicz D, et al. Dermatological changes during menopause and HRT: what to expect? Cosmetics. 2024;11(1):9.
  17. Merzel Sabovic EK, Kocjan T, Zalaudek I. Treatment of menopausal skin - A narrative review of existing treatments, controversies, and future perspectives. Post Reprod Health. 2024;30(2):85-94. Epub 20240220. doi: 10.1177/20533691241233440. PubMed PMID: 38379168.
  18. Dao H, Jr., Kazin RA. Gender differences in skin: a review of the literature. Gend Med. 2007;4(4):308-28. doi: 10.1016/s1550-8579(07)80061-1. PubMed PMID: 18215723.
  19. Blazer DG, Liverman CT. Testosterone and aging: clinical research directions. 2004.
  20. Daniell HW. Oral dehydroepiandrosterone might prevent frequent tears in atrophic skin: A case report. JAAD Case Rep. 2017;3(6):534-5. Epub 20171106. doi: 10.1016/j.jdcr.2017.09.019. PubMed PMID: 29264385; PubMed Central PMCID: PMC5728705.
  21. Nouveau S, Bastien P, Baldo F, de Lacharriere O. Effects of topical DHEA on aging skin: A pilot study. Maturitas. 2008;59(2):174-81. doi: 10.1016/j.maturitas.2007.12.004. PubMed PMID: WOS:000254939000008.
  22. Farage M, Miller KW, Zouboulis CC, Piérard G, Maibach H. Gender differences in skin aging and the changing profile of the sex hormones with age. J Steroids Horm Sci. 2012;3(2):109.
  23. Verdier-Sevrain S, Bonte F, Gilchrest B. Biology of estrogens in skin: implications for skin aging. Exp Dermatol. 2006;15(2):83-94. doi: 10.1111/j.1600-0625.2005.00377.x. PubMed PMID: 16433679.
  24. Carneiro JL, Haddad A, Righi IB, FERREIRA L. A promising alternative for mature skin: the effects of phytoestrogens on human skin and its topical use. Revista Brasileira de Cirurgia Plástica. 2023;38:e0685.
  25. Liu T, Li N, Yan YQ, Liu Y, Xiong K, Liu Y, et al. Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress. Phytother Res. 2020;34(3):435-47. Epub 20191120. doi: 10.1002/ptr.6538. PubMed PMID: 31747092; PubMed Central PMCID: PMC7078862.
  26. Svoboda RM, Del Rosso JQ, Zeichner JA, Draelos ZD. Revisiting the beneficial effects of estrogen on the skin: a comprehensive review of the literature and a look to the future. SKIN The Journal of Cutaneous Medicine. 2018;2(5).
  27. Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. International journal of dermatology. 1996;35(9):669-74.
  28. Elmets CA. Are Topical Estrogens Effective for Skin Aging? NEJM Journal Watch. 2008:JD200811070000001.
  29. Viscomi B, Muniz M, Sattler S. Managing Menopausal Skin Changes: A Narrative Review of Skin Quality Changes, Their Aesthetic Impact, and the Actual Role of Hormone Replacement Therapy in Improvement. Journal of Cosmetic Dermatology. 2025;24:e70393.
  30. Draelos ZD. A double-blind randomized pilot study evaluating the safety and efficacy of topical MEP in the facial appearance improvement of estrogen deficient females. Journal of Drugs in Dermatology: JDD. 2018;17(11):1186-9.
  31. Slominski A, Zbytek B, Nikolakis G, Manna PR, Skobowiat C, Zmijewski M, et al. Steroidogenesis in the skin: implications for local immune functions. The Journal of steroid biochemistry and molecular biology. 2013;137:107-23.
  32. Karakus E, Schmid A, Schäffler A, Wudy SA, Geyer J. Intracrine Formation of Steroid Hormones in Breast Cancer, Epidermal Keratinocyte, Dermal Fibroblast, and Adipocyte Cell Lines Measured by LC-MS/MS. International Journal of Molecular Sciences. 2025;26(3):1188.
  33. Bocheva G, Slominski RM, Slominski AT. Neuroendocrine aspects of skin aging. International journal of molecular sciences. 2019;20(11):2798.
  34. Manna PR, Stetson CL, Daugherty C, Shimizu I, Syapin PJ, Garrel G, et al. Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging. Mechanisms of ageing and development. 2015;150:74-82.
  35. Nguyen TT, Nguyen TTD, Van Vo G. Advances of microneedles in hormone delivery. Biomedicine & Pharmacotherapy. 2022;145:112393.
  36. Lim D-J, Kim H-J. Microneedles in action: microneedling and microneedles-assisted transdermal delivery. Polymers. 2022;14(8):1608.
  37. Gandhat S, Ugale S, Kumavat S, Gadge K, Dandawate N, Bhor V. Microneedles in Transdermal Drug Delivery: A Comprehensive Review. Journal of Drug Delivery & Therapeutics. 2025;15(6).
  38. Shaikh AA, Pawar JB, Anbhule SJ, Kakade VV. Review on nanoparticles for topical drug delivery. Int J Pharm Chem Anal. 2023;10(1):8-14.
  39. Lulseged BA, Ramaiyer MS, Michel R, Saad EE, Ozpolat B, Borahay MA. The role of nanomedicine in benign gynecologic disorders. Molecules. 2024;29(9):2095.
  40. Valenzuela P, Simon JA. Nanoparticle delivery for transdermal HRT. Nanomedicine: Nanotechnology, Biology and Medicine. 2012;8:S83-S9.
  41. Souto EB, Fernandes AR, Martins-Gomes C, Coutinho TE, Durazzo A, Lucarini M, et al. Nanomaterials for skin delivery of cosmeceuticals and pharmaceuticals. Applied Sciences. 2020;10(5):1594.
  42. Ahsan A, Tian W-X, Farooq MA, Khan DH. An overview of hydrogels and their role in transdermal drug delivery. International Journal of Polymeric Materials and Polymeric Biomaterials. 2021;70(8):574-84.
  43. Thang NH, Chien TB, Cuong DX. Polymer-based hydrogels applied in drug delivery: An overview. Gels. 2023;9(7):523.
  44. Ganesh K, Yang S, Schillace S, Vita V, Wang Y, Ehmann KF, et al. A review of manufacturing techniques for subcutaneous drug delivery implants. Procedia CIRP. 2022;110:329-34.
  45. Alum EU, Izah SC, Uti DE, Ugwu OP-C, Betiang PA, Basajja M, et al. Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics. Drug Design, Development and Therapy. 2025:8489-522.
  46. Suda M, Paul KH, Tripathi U, Minamino T, Tchkonia T, Kirkland JL. Targeting cell senescence and senolytics: novel interventions for age-related endocrine dysfunction. Endocrine reviews. 2024;45(5):655-75.
  47. Poljšak B, Kovač V, Špalj S, Milisav I. The central role of the NAD+ molecule in the development of aging and the prevention of chronic age-related diseases: strategies for NAD+ modulation. International journal of molecular sciences. 2023;24(3):2959.
  48. Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH. Dietary supplementation with NAD+-boosting compounds in humans: current knowledge and future directions. The Journals of Gerontology: Series A. 2023;78(12):2435-48.
  49. Masaki H. Role of antioxidants in the skin: anti-aging effects. Journal of dermatological science. 2010;58(2):85-90.
  50. Böhm M, Stegemann A, Paus R, Kleszczyński K, Maity P, Wlaschek M, et al. Endocrine controls of skin aging. Endocrine reviews. 2025;46(3):349-75.
  51. Lephart ED, Naftolin F. Factors Influencing Skin Aging and the Important Role of Estrogens and Selective Estrogen Receptor Modulators (SERMs). Clin Cosmet Investig Dermatol. 2022;15:1695-709. Epub 20220819. doi: 10.2147/CCID.S333663. PubMed PMID: 36017417; PubMed Central PMCID: PMC9397534.
  52. Lavretsky H, Newhouse PA. Stress, inflammation, and aging. Am J Geriatr Psychiatry. 2012;20(9):729-33. doi: 10.1097/JGP.0b013e31826573cf. PubMed PMID: 22874577; PubMed Central PMCID: PMC3428505.

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